Cargando…

Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1(G93A) ALS Mouse Model

Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by progressive motor neuron loss resulting in muscle atrophy, declining muscle function, and eventual paralysis. Patients typically die from respiratory failure 3 to 5 years from the onset of symptoms. Tirasemtiv is a fast s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwee, Darren T., Kennedy, Adam, Ryans, Julie, Russell, Alan J., Jia, Zhiheng, Hinken, Aaron C., Morgans, David J., Malik, Fady I., Jasper, Jeffrey R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013064/ https://www.ncbi.nlm.nih.gov/pubmed/24805850 http://dx.doi.org/10.1371/journal.pone.0096921

Ejemplares similares

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator
por: Collibee, Scott E., et al.
Publicado: (2018)

Functional Characterization of the Intact Diaphragm in a Nebulin-Based Nemaline Myopathy (NM) Model-Effects of the Fast Skeletal Muscle Troponin Activator tirasemtiv
por: Lee, Eun-Jeong, et al.
Publicado: (2019)

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans
por: Hansen, Richard, et al.
Publicado: (2014)

Fast skeletal muscle troponin activator CK‐2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction
por: Cheng, Arthur J., et al.
Publicado: (2019)

Fast skeletal muscle troponin activator CK‐2066260 mitigates skeletal muscle weakness independently of the underlying cause
por: Cheng, Arthur J., et al.
Publicado: (2020)

Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice
por: de Winter, Josine M, et al.
Publicado: (2021)

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
por: Russell, Alan J, et al.
Publicado: (2012)

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency
por: Lee, Eun-Jeong, et al.
Publicado: (2013)

The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle
por: Hwee, Darren T., et al.
Publicado: (2017)

Comparative Gene Expression Analysis in the Skeletal Muscles of Dysferlin-deficient SJL/J and A/J Mice
por: Kobayashi, Kinji, et al.
Publicado: (2011)

Cardiac troponin T and fast skeletal muscle denervation in ageing
por: Xu, Zherong, et al.
Publicado: (2017)

Time-Point Dependent Activation of Autophagy and the UPS in SOD1G93A Mice Skeletal Muscle
por: Oliván, Sara, et al.
Publicado: (2015)

Metabolic Changes Associated With Muscle Expression of SOD1(G93A)
por: Dobrowolny, Gabriella, et al.
Publicado: (2018)

Activation of the endoplasmic reticulum stress response in skeletal muscle of G93A*SOD1 amyotrophic lateral sclerosis mice
por: Chen, Dapeng, et al.
Publicado: (2015)

Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T
por: du Fay de Lavallaz, Jeanne, et al.
Publicado: (2022)

Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1(G93A) Mice Predates Disease Onset and Is A Promising Therapeutic Target
por: Scaricamazza, Silvia, et al.
Publicado: (2020)

Troponin Variants as Markers of Skeletal Muscle Health and Diseases
por: Rasmussen, Monica, et al.
Publicado: (2021)

Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice
por: Nagahisa, Hiroshi, et al.
Publicado: (2016)

A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis
por: Sanders, Donald B., et al.
Publicado: (2015)

Nerve Terminal Degeneration Is Independent of Muscle Fiber Genotype in SOD1(G93A) Mice
por: Carrasco, Dario I., et al.
Publicado: (2010)

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations
por: de Winter, Josine Marieke, et al.
Publicado: (2013)

Developing Cardiac and Skeletal Muscle Share Fast-Skeletal Myosin Heavy Chain and Cardiac Troponin-I Expression
por: Clause, Kelly C., et al.
Publicado: (2012)

P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
por: Fabbrizio, Paola, et al.
Publicado: (2019)

Intermolecular And Dynamic Investigation of The Mechanism of Action of Reldesemtiv on Fast Skeletal Muscle Troponin Complex Toward the Treatment of Impaired Muscle Function
por: Issahaku, Abdul Rashid, et al.
Publicado: (2023)

Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
por: Heyer, Laurent, et al.
Publicado: (2009)

Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics
por: van de Locht, Martijn, et al.
Publicado: (2021)

Muscle atrophy induced by SOD1(G93A )expression does not involve the activation of caspase in the absence of denervation
por: Dobrowolny, Gabriella, et al.
Publicado: (2011)

SOD2 in skeletal muscle: New insights from an inducible deletion model
por: Zhuang, Aowen, et al.
Publicado: (2021)

Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy
Publicado: (1981)

Troponin in embryonic chick skeletal muscle cells in vitro. An immunoelectron microscope study
Publicado: (1979)

CARDIAC TROPONIN T MEDIATED AUTOIMMUNE RESPONSE AND ITS ROLE IN SKELETAL MUSCLE AGING
por: Zhang, Tan, et al.
Publicado: (2019)

The Effects of Bee Venom Acupuncture on the Central Nervous System and Muscle in an Animal hSOD1(G93A) Mutant
por: Cai, MuDan, et al.
Publicado: (2015)

Characterization of Dysferlin Deficient SJL/J Mice to Assess Preclinical Drug Efficacy: Fasudil Exacerbates Muscle Disease Phenotype
por: Rayavarapu, Sree, et al.
Publicado: (2010)

Combined Treatment with Bojungikgi-Tang and Riluzole Regulates Muscle Metabolism and Dysfunction in the hSOD1(G93A) Mouse Model
por: Cai, Mudan, et al.
Publicado: (2022)

Suppression of IgE antibody production in SJL mice. III. Characterization of a suppressor substance extracted from normal SJL spleen cells
Publicado: (1977)

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
por: Hinken, Aaron C., et al.
Publicado: (2016)

GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells
por: Di Lisi, Raffaella, et al.
Publicado: (2007)

Protein kinase A–dependent modulation of Ca(2+) sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin
por: Matsuba, Douchi, et al.
Publicado: (2009)

Neuromuscular effects of G93A-SOD1 expression in zebrafish
por: Sakowski, Stacey A, et al.
Publicado: (2012)

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis
por: Wang, Haitao A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n85640rounnamoefostihs0mg0