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Functional Characterization Improves Associations between Rare Non-Synonymous Variants in CHRNB4 and Smoking Behavior

Smoking is the leading cause of preventable death worldwide. Accordingly, effort has been devoted to determining the genetic variants that contribute to smoking risk. Genome-wide association studies have identified several variants in nicotinic acetylcholine receptor genes that contribute to nicotin...

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Detalles Bibliográficos
Autores principales: Haller, Gabe, Li, Ping, Esch, Caroline, Hsu, Simon, Goate, Alison M., Steinbach, Joe Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013067/
https://www.ncbi.nlm.nih.gov/pubmed/24804708
http://dx.doi.org/10.1371/journal.pone.0096753