Cargando…

FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity

Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1 (mTORC1) activity via p70 S6 kinase 1 (S6K1)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Bartley, Christopher M., O’Keefe, Rachel A., Bordey, Angélique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013076/ https://www.ncbi.nlm.nih.gov/pubmed/24806451 http://dx.doi.org/10.1371/journal.pone.0096956

Ejemplares similares

Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP
por: Bartley, Christopher M., et al.
Publicado: (2016)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Comparison of Equivalence between Two Commercially Available S499-Phosphorylated FMRP Antibodies in Mice
por: Reynolds, Conner D., et al.
Publicado: (2015)

Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells
por: Ahmed, Abdullah R., et al.
Publicado: (2019)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

4E-BP1 expression in embryonic postmitotic neurons mitigates mTORC1-induced cortical malformations and behavioral seizure severity but does not prevent epilepsy in mice
por: Nguyen, Lena H., et al.
Publicado: (2023)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging
por: Ming, Xiu-Fen, et al.
Publicado: (2012)

mTORC1 phosphorylates LARP6 to stimulate type I collagen expression
por: Zhang, Yujie, et al.
Publicado: (2017)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
por: Yuan, Hai-Xin, et al.
Publicado: (2015)

mTORc1 activity is necessary and sufficient for phosphorylation of eNOS(S1177)
por: Decker, Brandee, et al.
Publicado: (2018)

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
por: Jewell, Jenna L, et al.
Publicado: (2019)

Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
por: Ren, Qian‐Nan, et al.
Publicado: (2021)

Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis
por: Wang, Guoyan, et al.
Publicado: (2023)

The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling
por: Nayak, Tanmoyita, et al.
Publicado: (2018)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
por: Antonia, Ricardo J., et al.
Publicado: (2019)

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1
por: Kaeser-Pebernard, Stéphanie, et al.
Publicado: (2022)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity
por: Kalim, Khalid W., et al.
Publicado: (2017)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors
por: Harter, Patrick N., et al.
Publicado: (2015)

mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
por: Alayev, A, et al.
Publicado: (2015)

mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
por: Fort, Patrice E., et al.
Publicado: (2014)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
por: Werzowa, Johannes, et al.
Publicado: (2010)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_06eeuo5j4u93nbl96a0n15i75a