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Specific Epiblast Loss and Hypoblast Impairment in Cattle Embryos Sensitized to Survival Signalling by Ubiquitous Overexpression of the Proapoptotic Gene BAD
Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the proapoptotic protein BAD. Two primary fibroblas...
Autores principales: | van Leeuwen, Jessica, Berg, Debra K., Smith, Craig S., Wells, David N., Pfeffer, Peter L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013130/ https://www.ncbi.nlm.nih.gov/pubmed/24806443 http://dx.doi.org/10.1371/journal.pone.0096843 |
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