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Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning

Cytoplasmic dynein is recruited to the cell cortex in early mitosis, where it can generate pulling forces on astral microtubules to position the mitotic spindle. Recent work has shown that dynein displays a dynamic asymmetric cortical localization, and that dynein recruitment is negatively regulated...

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Detalles Bibliográficos
Autores principales: Tame, Mihoko A, Raaijmakers, Jonne A, van den Broek, Bram, Lindqvist, Arne, Jalink, Kees, Medema, René H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013166/
https://www.ncbi.nlm.nih.gov/pubmed/24553118
http://dx.doi.org/10.4161/cc.28031