Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4(+)25(+)Foxp3(+) Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation

Dendritic cells (DCs), the most potent antigen-presenting cells have been extensively applied in clinical trials for evaluation of antitumor immunity. However, the efficacy of DC-mediated cancer vaccines is still limited as they are unable to sufficiently break the immune tolerance. In this study, w...

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Detalles Bibliográficos
Autores principales: Bhanumathy, Kalpana Kalyanasundaram, Zhang, Bei, Ahmed, Khawaja Ashfaque, Qureshi, Mabood, Xie, Yufeng, Tao, Min, Tan, Xin, Xiang, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013578/
https://www.ncbi.nlm.nih.gov/pubmed/24690994
http://dx.doi.org/10.3390/ijms15045508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013578/
https://www.ncbi.nlm.nih.gov/pubmed/24690994
http://dx.doi.org/10.3390/ijms15045508

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