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Gentamicin Blocks the ACh-Induced BK Current in Guinea Pig Type II Vestibular Hair Cells by Competing with Ca(2+) at the l-Type Calcium Channel

Type II vestibular hair cells (VHCs II) contain big-conductance Ca(2+)-dependent K(+) channels (BK) and l-type calcium channels. Our previous studies in guinea pig VHCs II indicated that acetylcholine (ACh) evoked the BK current by triggering the influx of Ca(2+) ions through l-type Ca(2+) channels,...

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Detalles Bibliográficos
Autores principales: Yu, Hong, Guo, Chang-Kai, Wang, Yi, Zhou, Tao, Kong, Wei-Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013660/
https://www.ncbi.nlm.nih.gov/pubmed/24758923
http://dx.doi.org/10.3390/ijms15046757