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Proinflammatory-activated glioma cells induce a switch in microglial polarization and activation status, from a predominant M2b phenotype to a mixture of M1 and M2a/B polarized cells

Malignant gliomas are primary brain tumors characterized by morphological and genetic complexities, as well as diffuse infiltration into normal brain parenchyma. Within gliomas, microglia/macrophages represent the largest tumor-infiltrating cell population, contributing by at least one-third to the...

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Detalles Bibliográficos
Autores principales: Lisi, Lucia, Stigliano, Egidio, Lauriola, Libero, Navarra, Pierluigi, Russo, Cinzia Dello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013688/
https://www.ncbi.nlm.nih.gov/pubmed/24689533
http://dx.doi.org/10.1042/AN20130045