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Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically
The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatm...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013765/ https://www.ncbi.nlm.nih.gov/pubmed/24549183 http://dx.doi.org/10.1038/jcbfm.2014.28 |
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author | Sena, Emily S Currie, Gillian L McCann, Sarah K Macleod, Malcolm R Howells, David W |
author_facet | Sena, Emily S Currie, Gillian L McCann, Sarah K Macleod, Malcolm R Howells, David W |
author_sort | Sena, Emily S |
collection | PubMed |
description | The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. The aim of this review is to describe the concepts of systematic review and meta-analysis and consider how these tools may be used to provide empirical evidence to spur the field to improve the rigor of the conduct and reporting of preclinical research akin to their use in improving the conduct and reporting of randomized controlled trials in clinical research. As with other research domains, systematic reviews are subject to bias. Therefore, we have also suggested guidance for their conduct, reporting, and critical appraisal. |
format | Online Article Text |
id | pubmed-4013765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40137652014-05-13 Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically Sena, Emily S Currie, Gillian L McCann, Sarah K Macleod, Malcolm R Howells, David W J Cereb Blood Flow Metab Review Article The use of systematic review and meta-analysis of preclinical studies has become more common, including those of studies describing the modeling of cerebrovascular diseases. Empirical evidence suggests that too many preclinical experiments lack methodological rigor, and this leads to inflated treatment effects. The aim of this review is to describe the concepts of systematic review and meta-analysis and consider how these tools may be used to provide empirical evidence to spur the field to improve the rigor of the conduct and reporting of preclinical research akin to their use in improving the conduct and reporting of randomized controlled trials in clinical research. As with other research domains, systematic reviews are subject to bias. Therefore, we have also suggested guidance for their conduct, reporting, and critical appraisal. Nature Publishing Group 2014-05 2014-02-19 /pmc/articles/PMC4013765/ /pubmed/24549183 http://dx.doi.org/10.1038/jcbfm.2014.28 Text en Copyright © 2014 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Review Article Sena, Emily S Currie, Gillian L McCann, Sarah K Macleod, Malcolm R Howells, David W Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title | Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title_full | Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title_fullStr | Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title_full_unstemmed | Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title_short | Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
title_sort | systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013765/ https://www.ncbi.nlm.nih.gov/pubmed/24549183 http://dx.doi.org/10.1038/jcbfm.2014.28 |
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