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Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration

OBJECTIVE: To test the hypotheses predicted in a hypothetical model of Alzheimer disease (AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to hippocampal neurodegeneration whereas rates of neurodegenerative brain atrophy depend on the presence of both amyloid a...

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Detalles Bibliográficos
Autores principales: Jack, Clifford R., Wiste, Heather J., Knopman, David S., Vemuri, Prashanthi, Mielke, Michelle M., Weigand, Stephen D., Senjem, Matthew L., Gunter, Jeffrey L., Lowe, Val, Gregg, Brian E., Pankratz, Vernon S., Petersen, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013810/
https://www.ncbi.nlm.nih.gov/pubmed/24706010
http://dx.doi.org/10.1212/WNL.0000000000000386