Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key adaptor protein Act1. SEFIR-mediated protein–protein interaction is a crucial...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Bing, Liu, Caini, Qian, Wen, Han, Yue, Li, Xiaoxia, Deng, Junpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014126/
https://www.ncbi.nlm.nih.gov/pubmed/24816115
http://dx.doi.org/10.1107/S1399004714005227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014126/
https://www.ncbi.nlm.nih.gov/pubmed/24816115
http://dx.doi.org/10.1107/S1399004714005227

Ejemplares similares