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Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling

Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key adaptor protein Act1. SEFIR-mediated protein–protein interaction is a crucial...

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Detalles Bibliográficos
Autores principales:	Zhang, Bing, Liu, Caini, Qian, Wen, Han, Yue, Li, Xiaoxia, Deng, Junpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014126/ https://www.ncbi.nlm.nih.gov/pubmed/24816115 http://dx.doi.org/10.1107/S1399004714005227

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