Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction

Human ATP13A2 (PARK9), a lysosomal type 5 P-type ATPase, has been associated with autosomal recessive early-onset Parkinson's disease (PD). ATP13A2 encodes a protein that is highly expressed in neurons and is predicted to function as a cation pump, although the substrate specificity remains unc...

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Detalles Bibliográficos
Autores principales: Park, Jin-Sung, Koentjoro, Brianada, Veivers, David, Mackay-Sim, Alan, Sue, Carolyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014187/
https://www.ncbi.nlm.nih.gov/pubmed/24399444
http://dx.doi.org/10.1093/hmg/ddt623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014187/
https://www.ncbi.nlm.nih.gov/pubmed/24399444
http://dx.doi.org/10.1093/hmg/ddt623

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