Defective sphingosine-1-phosphate receptor 1 (S1P(1)) phosphorylation exacerbates T(H)17-mediated autoimmune neuroinflammation

Sphingosine-1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. Sphingosine phosphate receptor 1 (S1P(1)) agonist, FTY-720 (Gilenya™) arrests immune trafficking and prevents multiple sclerosis (MS) relapses. However, alternative mechanisms of S1P-S...

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Detalles Bibliográficos
Autores principales: Garris, Christopher S., Wu, Linfeng, Acharya, Swati, Arac, Ahmet, Blaho, Victoria A., Huang, Yingxiang, Moon, Byoung San, Axtell, Robert C., Ho, Peggy P., Steinberg, Gary K., Lewis, David B., Sobel, Raymond A., Han, David K., Steinman, Lawrence, Snyder, Michael P., Hla, Timothy, Han, May H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014310/
https://www.ncbi.nlm.nih.gov/pubmed/24076635
http://dx.doi.org/10.1038/ni.2730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014310/
https://www.ncbi.nlm.nih.gov/pubmed/24076635
http://dx.doi.org/10.1038/ni.2730

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