Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus

Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial dendritic spine loss. The effect of some of th...

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Detalles Bibliográficos
Autores principales: Tejada, Julian, Garcia-Cairasco, Norberto, Roque, Antonio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014389/
https://www.ncbi.nlm.nih.gov/pubmed/24811867
http://dx.doi.org/10.1371/journal.pcbi.1003601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014389/
https://www.ncbi.nlm.nih.gov/pubmed/24811867
http://dx.doi.org/10.1371/journal.pcbi.1003601

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