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dGTP Starvation in Escherichia coli Provides New Insights into the Thymineless-Death Phenomenon
Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The phenomenon, discovered some 60 years ago, is widely used to kill cells in anticancer therapies, but many questions regarding the precise underlying mec...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014421/ https://www.ncbi.nlm.nih.gov/pubmed/24810600 http://dx.doi.org/10.1371/journal.pgen.1004310 |