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dGTP Starvation in Escherichia coli Provides New Insights into the Thymineless-Death Phenomenon

Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The phenomenon, discovered some 60 years ago, is widely used to kill cells in anticancer therapies, but many questions regarding the precise underlying mec...

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Detalles Bibliográficos
Autores principales:	Itsko, Mark, Schaaper, Roel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014421/ https://www.ncbi.nlm.nih.gov/pubmed/24810600 http://dx.doi.org/10.1371/journal.pgen.1004310

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