Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities

Inactivation of the Rb tumor suppressor can lead to increased cell proliferation or cell death depending on specific cellular context. Therefore, identification of the interacting pathways that modulate the effect of Rb loss will provide novel insights into the roles of Rb in cancer development and...

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Detalles Bibliográficos
Autores principales: Zhang, Tianyi, Liao, Yang, Hsu, Fu-Ning, Zhang, Robin, Searle, Jennifer S., Pei, Xun, Li, Xuan, Ryoo, Hyung Don, Ji, Jun-Yuan, Du, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014429/
https://www.ncbi.nlm.nih.gov/pubmed/24809668
http://dx.doi.org/10.1371/journal.pgen.1004357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014429/
https://www.ncbi.nlm.nih.gov/pubmed/24809668
http://dx.doi.org/10.1371/journal.pgen.1004357

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