Cargando…

Mlh2 Is an Accessory Factor for DNA Mismatch Repair in Saccharomyces cerevisiae

In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear. Mlh1-Mlh2 formed foci that often colocalized with and had...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campbell, Christopher S., Hombauer, Hans, Srivatsan, Anjana, Bowen, Nikki, Gries, Kerstin, Desai, Arshad, Putnam, Christopher D., Kolodner, Richard D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014439/ https://www.ncbi.nlm.nih.gov/pubmed/24811092 http://dx.doi.org/10.1371/journal.pgen.1004327

Ejemplares similares

Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway
por: Smith, Catherine E., et al.
Publicado: (2013)

Activation of Saccharomyces cerevisiae Mlh1-Pms1 Endonuclease in a Reconstituted Mismatch Repair System
por: Smith, Catherine E., et al.
Publicado: (2015)

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae
por: Calil, Felipe A., et al.
Publicado: (2021)

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
por: Reyes, Gloria X., et al.
Publicado: (2020)

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
por: DuPrie, Matthew L., et al.
Publicado: (2022)

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae
por: Putnam, Christopher D., et al.
Publicado: (2017)

Ligation of newly replicated DNA controls the timing of DNA mismatch repair
por: Reyes, Gloria X., et al.
Publicado: (2021)

Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae
por: Li, Bin-zhong, et al.
Publicado: (2020)

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
por: Putnam, Christopher D., et al.
Publicado: (2016)

Cdc73 suppresses genome instability by mediating telomere homeostasis
por: Nene, Rahul V., et al.
Publicado: (2018)

The properties of Msh2–Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
por: Graham, William J., et al.
Publicado: (2018)

Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
por: Enserink, Jorrit M., et al.
Publicado: (2009)

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects
por: Srivatsan, Anjana, et al.
Publicado: (2018)

The unstructured linker of Mlh1 contains a motif required for endonuclease function which is mutated in cancers
por: Torres, Kendall A., et al.
Publicado: (2022)

Rapid Analysis of Saccharomyces cerevisiae Genome Rearrangements by Multiplex Ligation–Dependent Probe Amplification
por: Chan, Jason E., et al.
Publicado: (2012)

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair
por: Furman, Christopher M, et al.
Publicado: (2021)

Involvement of DNA mismatch repair in the maintenance of heterochromatic DNA stability in Saccharomyces cerevisiae
por: Dahal, Basanta K., et al.
Publicado: (2017)

Mismatch Repair Genes Mlh1 and Mlh3 Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches
por: Pinto, Ricardo Mouro, et al.
Publicado: (2013)

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair
por: Miller, Anna K., et al.
Publicado: (2022)

FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination
por: Guo, Elaine, et al.
Publicado: (2020)

Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae
por: Enserink, Jorrit M., et al.
Publicado: (2006)

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans
por: Manhart, Carol M., et al.
Publicado: (2017)

DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells
por: Fukuhara, Shinichiro, et al.
Publicado: (2014)

Post-Replication Repair Suppresses Duplication-Mediated Genome Instability
por: Putnam, Christopher D., et al.
Publicado: (2010)

Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
por: Fink, D., et al.
Publicado: (1997)

Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
por: Plotz, Guido, et al.
Publicado: (2006)

Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein
por: Dominguez-Valentin, Mev, et al.
Publicado: (2014)

Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β
por: Lu, Jun-Yu, et al.
Publicado: (2017)

MLH1 promoter hypermethylation predicts poorer prognosis in mismatch repair deficiency endometrial carcinomas
por: Kaneko, Enami, et al.
Publicado: (2021)

DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
por: Martin, Sarah A., et al.
Publicado: (2010)

Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics
por: Li, Yan, et al.
Publicado: (2019)

Peroxiredoxin Tsa1 Is the Key Peroxidase Suppressing Genome Instability and Protecting against Cell Death in Saccharomyces cerevisiae
por: Iraqui, Ismail, et al.
Publicado: (2009)

Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1
por: He, Wei, et al.
Publicado: (2008)

DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage
por: Wakeman, Timothy P., et al.
Publicado: (2017)

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer
por: Loukovaara, Mikko, et al.
Publicado: (2021)

The Impact of Ageing on CHITIN Scars in Saccharomyces cerevisiae
por: Powell, Christopher D., et al.
Publicado: (2001)

Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer
por: Benachenhou, N, et al.
Publicado: (1999)

DNA Repair Pathway Selection Caused by Defects in TEL1, SAE2, and De Novo Telomere Addition Generates Specific Chromosomal Rearrangement Signatures
por: Putnam, Christopher D., et al.
Publicado: (2014)

Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1
por: Leal, Marcelo C., et al.
Publicado: (2008)

Brewer’s Yeast, Saccharomyces cerevisiae, Enhances Attraction of Two Invasive Yellowjackets (Hymenoptera: Vespidae) to Dried Fruit and Fruit Powder
por: Babcock, Tamara, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kcsgm72ttsvls2itfi3kko7t8a