Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

Alpha-synuclein (aSyn) is the main component of proteinaceous inclusions known as Lewy bodies (LBs), the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Although aSyn is phosphorylated at low levels under physiological conditions, it is estimated that ∼90%...

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Detalles Bibliográficos
Autores principales: Tenreiro, Sandra, Reimão-Pinto, Madalena M., Antas, Pedro, Rino, José, Wawrzycka, Donata, Macedo, Diana, Rosado-Ramos, Rita, Amen, Triana, Waiss, Meytal, Magalhães, Filipa, Gomes, Andreia, Santos, Cláudia N., Kaganovich, Daniel, Outeiro, Tiago Fleming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014446/
https://www.ncbi.nlm.nih.gov/pubmed/24810576
http://dx.doi.org/10.1371/journal.pgen.1004302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014446/
https://www.ncbi.nlm.nih.gov/pubmed/24810576
http://dx.doi.org/10.1371/journal.pgen.1004302

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