The Deficiency of Tumor Suppressor Prep1 Accelerates the Onset of Meis1- Hoxa9 Leukemogenesis

Prep1 and Meis1 ortholog TALE transcription factors have opposing roles in tumorigenesis: Meis1 serves as an oncogene, Prep1 as a tumor suppressor. We now report that, Meis1 overexpression in primary Prep1-deficient (Prep1(i/i)) embryonic hematopoietic cells increases self-renewal potential of cells...

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Detalles Bibliográficos
Autores principales: Dardaei, Leila, Modica, Livia, Iotti, Giorgio, Blasi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014505/
https://www.ncbi.nlm.nih.gov/pubmed/24809472
http://dx.doi.org/10.1371/journal.pone.0096711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014505/
https://www.ncbi.nlm.nih.gov/pubmed/24809472
http://dx.doi.org/10.1371/journal.pone.0096711

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