Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells

The Hedgehog-GLI signaling pathway is active in a variety of human malignancies and is known to contribute to the growth and survival of human osteosarcoma cells. In this study, we examined the expression and regulation of GLI transcription factors in multiple canine osteosarcoma cell lines and anal...

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Detalles Bibliográficos
Autores principales: Shahi, Mehdi Hayat, Holt, Roseline, Rebhun, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014515/
https://www.ncbi.nlm.nih.gov/pubmed/24810746
http://dx.doi.org/10.1371/journal.pone.0096593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014515/
https://www.ncbi.nlm.nih.gov/pubmed/24810746
http://dx.doi.org/10.1371/journal.pone.0096593

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