Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags

The affinity-mediated selection of large libraries of DNA-encoded small molecules is increasingly being used to initiate drug discovery programs. We present universal methods for the encoding of such libraries using the chemical ligation of oligonucleotides. These methods may be used to record the c...

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Detalles Bibliográficos
Autores principales: Litovchick, Alexander, Clark, Matthew A, Keefe, Anthony D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014522/
https://www.ncbi.nlm.nih.gov/pubmed/25483841
http://dx.doi.org/10.4161/adna.27896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014522/
https://www.ncbi.nlm.nih.gov/pubmed/25483841
http://dx.doi.org/10.4161/adna.27896

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