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Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags
The affinity-mediated selection of large libraries of DNA-encoded small molecules is increasingly being used to initiate drug discovery programs. We present universal methods for the encoding of such libraries using the chemical ligation of oligonucleotides. These methods may be used to record the c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014522/ https://www.ncbi.nlm.nih.gov/pubmed/25483841 http://dx.doi.org/10.4161/adna.27896 |