Cargando…
Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin
Endotoxemia plays a major causative role in the myocardial injury and dysfunction associated with sepsis. Extracellular hemoglobin (Hb) has been shown to enhance the pathophysiology of endotoxemia. In the present study, we examined the myocardial pathophysiology in guinea pigs infused with lipopolys...
Autores principales: | Baek, Jin Hyen, Zhang, Xiaoyuan, Williams, Matthew C., Schaer, Dominik J., Buehler, Paul W., D’Agnillo, Felice |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014731/ https://www.ncbi.nlm.nih.gov/pubmed/24691127 http://dx.doi.org/10.3390/toxins6041244 |
Ejemplares similares
-
Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin
por: Rentsendorj, Otgonchimeg, et al.
Publicado: (2016) -
Renal glomerular and tubular responses to glutaraldehyde- polymerized human hemoglobin
por: Williams, Matthew C., et al.
Publicado: (2023) -
Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications
por: Boretti, Felicitas S., et al.
Publicado: (2014) -
Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway
por: Warfel, Jason M., et al.
Publicado: (2011) -
Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics
por: Schaer, Christian A., et al.
Publicado: (2018)