Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Background: Quantitative estimation of toxicokinetic variability in the human population is a persistent challenge in risk assessment of environmental chemicals. Traditionally, interindividual differences in the population are accounted for by default assumptions or, in rare cases, are based on huma...

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Detalles Bibliográficos
Autores principales: Chiu, Weihsueh A., Campbell, Jerry L., Clewell, Harvey J., Zhou, Yi-Hui, Wright, Fred A., Guyton, Kathryn Z., Rusyn, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NLM-Export 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014769/
https://www.ncbi.nlm.nih.gov/pubmed/24518055
http://dx.doi.org/10.1289/ehp.1307623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014769/
https://www.ncbi.nlm.nih.gov/pubmed/24518055
http://dx.doi.org/10.1289/ehp.1307623

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