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The tetrapeptide core of the carrier peptide Xentry is cell-penetrating: novel activatable forms of Xentry

Here we describe a structure-function analysis of the cell-penetrating peptide Xentry derived from the X-protein of the hepatitis B virus. Remarkably, the tetrapeptide core LCLR retains the cell-penetrating ability of the parental peptide LCLRPVG, as either an L- or D-enantiomer. Substitution of the...

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Detalles Bibliográficos
Autores principales: Montrose, Kristopher, Yang, Yi, Krissansen, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014984/
https://www.ncbi.nlm.nih.gov/pubmed/24811205
http://dx.doi.org/10.1038/srep04900