Transcriptional Repressor Domain of MBD1 is Intrinsically Disordered and Interacts with its Binding Partners in a Selective Manner

Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins...

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Detalles Bibliográficos
Autores principales: Hameed, Umar Farook Shahul, Lim, Jackwee, Zhang, Qian, Wasik, Mariusz A., Yang, Daiwen, Swaminathan, Kunchithapadam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014985/
https://www.ncbi.nlm.nih.gov/pubmed/24810720
http://dx.doi.org/10.1038/srep04896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014985/
https://www.ncbi.nlm.nih.gov/pubmed/24810720
http://dx.doi.org/10.1038/srep04896

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