Cargando…

Transcriptional Repressor Domain of MBD1 is Intrinsically Disordered and Interacts with its Binding Partners in a Selective Manner

Methylation of DNA CpG sites is a major mechanism of epigenetic gene silencing and plays important roles in cell division, development and carcinogenesis. One of its regulators is the 64-residue C-terminal Transcriptional Repressor Domain (the TRD) of MBD1, which recruits several repressor proteins...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hameed, Umar Farook Shahul, Lim, Jackwee, Zhang, Qian, Wasik, Mariusz A., Yang, Daiwen, Swaminathan, Kunchithapadam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014985/ https://www.ncbi.nlm.nih.gov/pubmed/24810720 http://dx.doi.org/10.1038/srep04896

Ejemplares similares

The Transcriptional Repressor Domain of Gli3 Is Intrinsically Disordered
por: Tsanev, Robert, et al.
Publicado: (2013)

A NR2E1‐interacting peptide of LSD1 inhibits the proliferation of brain tumour initiating cells
por: Hu, Rong, et al.
Publicado: (2022)

Methyl CpG binding domain protein 2 (MBD2) in inflammation
por: Lei, Qian, et al.
Publicado: (2022)

Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8
por: Lim, Jackwee, et al.
Publicado: (2011)

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
por: Desai, Megha A., et al.
Publicado: (2015)

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)

An Epigenetic Regulator: Methyl-CpG-Binding Domain Protein 1 (MBD1)
por: Li, Lu, et al.
Publicado: (2015)

The Human Proteins MBD5 and MBD6 Associate with Heterochromatin but They Do Not Bind Methylated DNA
por: Laget, Sophie, et al.
Publicado: (2010)

Lactose repressor hinge domain independently binds DNA
por: Xu, Joseph S., et al.
Publicado: (2018)

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner
por: dos Santos, Rodrigo L., et al.
Publicado: (2014)

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner
por: dos Santos, Rodrigo L., et al.
Publicado: (2014)

The impacts of allopolyploidization on Methyl-CpG-Binding Domain (MBD) gene family in Brassica napus
por: Xiao, Yafang, et al.
Publicado: (2022)

Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2
por: Kim, Min Young, et al.
Publicado: (2019)

MBD2 and MBD3: elusive functions and mechanisms
por: Menafra, Roberta, et al.
Publicado: (2014)

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
por: Günther, Katharina, et al.
Publicado: (2013)

Passenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein
por: Momin, Afaque A., et al.
Publicado: (2019)

Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition
por: Lax, Elad, et al.
Publicado: (2023)

Impact of cinacalcet introduction on MBD management: the MBD-5D study in Japan
por: Fukuma, Shingo, et al.
Publicado: (2013)

Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from Arabidopsis thaliana
por: Mahana, Yutaka, et al.
Publicado: (2022)

Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains
por: Cong, Le, et al.
Publicado: (2012)

Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence
por: Scarsdale, J. Neel, et al.
Publicado: (2011)

The methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons
por: Zhao, Na, et al.
Publicado: (2015)

Prevention and Treatment of CKD-MBD
por: Cozzolino, Mario
Publicado: (2013)

MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis
por: Yue, Tiantian, et al.
Publicado: (2021)

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors
por: Kumar, Shiva, et al.
Publicado: (2011)

DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells
por: Hainer, Sarah J, et al.
Publicado: (2016)

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
por: Melters, Daniël P., et al.
Publicado: (2019)

The methyl binding domain containing protein MBD5 is a transcriptional regulator responsible for 2q23.1 deletion syndrome
por: Walz, Katherina, et al.
Publicado: (2014)

Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
por: Miyamoto, Takafumi, et al.
Publicado: (2017)

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer
por: Tsuboyama, Natsumi, et al.
Publicado: (2022)

Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner
por: Kuciak, Monika, et al.
Publicado: (2019)

Destabilizing single chain major histocompatibility complex class I protein for repurposed enterokinase proteolysis
por: Lim, Jackwee
Publicado: (2020)

Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements
por: Otteson, Deborah C, et al.
Publicado: (2005)

CKD-MBD after kidney transplantation
por: Wesseling-Perry, Katherine, et al.
Publicado: (2011)

A Japanese approach for CKD-MBD
por: Yokoyama, Keitaro, et al.
Publicado: (2013)

The Role of Vitamin K in CKD-MBD
por: Fusaro, Maria, et al.
Publicado: (2022)

CKD-MBD diagnosis: biochemical abnormalities
por: Lucca, Leandro Junior, et al.
Publicado: (2021)

Genome-Wide Binding of MBD2 Reveals Strong Preference for Highly Methylated Loci
por: Menafra, Roberta, et al.
Publicado: (2014)

MECP2 missense mutations outside the canonical MBD and TRD domains in males with intellectual disability
por: Bianciardi, Laura, et al.
Publicado: (2015)

Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners
por: Hill, Stephanie A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5pb8isoggf85p6n22499stp1kv