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Stress induced telomere shortening: longer life with less mutations?
BACKGROUND: Mutations accumulate as a result of DNA damage and imperfect DNA repair machinery. In higher eukaryotes the accumulation and spread of mutations is limited in two primary ways: through p53-mediated programmed cell death and cellular senescence mediated by telomeres. Telomeres shorten at...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015310/ https://www.ncbi.nlm.nih.gov/pubmed/24580844 http://dx.doi.org/10.1186/1752-0509-8-27 |