FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H(2)O(2) accumulation

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival. FoxO transcription factors counteract ROS generation by upregulating antioxidant enzymes. H...

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Detalles Bibliográficos
Autores principales: Bartell, Shoshana M., Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhya, Serra Ucer, S., Rabinovitch, Peter, Jilka, Robert L., Weinstein, Robert S., Zhao, Haibo, O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015330/
https://www.ncbi.nlm.nih.gov/pubmed/24781012
http://dx.doi.org/10.1038/ncomms4773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015330/
https://www.ncbi.nlm.nih.gov/pubmed/24781012
http://dx.doi.org/10.1038/ncomms4773

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