Lysosomal NEU1 deficiency affects Amyloid Precursor Protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Alzheimer’s disease (AD) belongs to a category of adult neurodegenerative conditions which are associated with intracellular and extracellular accumulation of neurotoxic protein aggregates. Understanding how these aggregates are formed, secreted and propagated by neurons has been the subject of inte...

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Detalles Bibliográficos
Autores principales: Annunziata, Ida, Patterson, Annette, Helton, Danielle, Hu, Huimin, Moshiach, Simon, Gomero, Elida, Nixon, Ralph, d’Azzo, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015463/
https://www.ncbi.nlm.nih.gov/pubmed/24225533
http://dx.doi.org/10.1038/ncomms3734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015463/
https://www.ncbi.nlm.nih.gov/pubmed/24225533
http://dx.doi.org/10.1038/ncomms3734

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