Stress-induced cleavage of Myc promotes cancer cell survival

Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated proteolysis of Myc. This generates Myc-nick, a cytoplasmic, transcriptionally inactive cleavage product of Myc. We found conversion of Myc into...

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Detalles Bibliográficos
Autores principales: Conacci-Sorrell, Maralice, Ngouenet, Celine, Anderson, Sarah, Brabletz, Thomas, Eisenman, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015487/
https://www.ncbi.nlm.nih.gov/pubmed/24696454
http://dx.doi.org/10.1101/gad.231894.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015487/
https://www.ncbi.nlm.nih.gov/pubmed/24696454
http://dx.doi.org/10.1101/gad.231894.113

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