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Stress-induced cleavage of Myc promotes cancer cell survival
Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated proteolysis of Myc. This generates Myc-nick, a cytoplasmic, transcriptionally inactive cleavage product of Myc. We found conversion of Myc into...
Autores principales: | Conacci-Sorrell, Maralice, Ngouenet, Celine, Anderson, Sarah, Brabletz, Thomas, Eisenman, Robert N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015487/ https://www.ncbi.nlm.nih.gov/pubmed/24696454 http://dx.doi.org/10.1101/gad.231894.113 |
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