A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis

In animals, piRNAs and their associated Piwi proteins guard germ cell genomes against mobile genetic elements via an RNAi-like mechanism. In Caenorhabditis elegans, 21U-RNAs comprise the piRNA class, and these collaborate with 22G RNAs via unclear mechanisms to discriminate self from nonself and sel...

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Detalles Bibliográficos
Autores principales: Goh, Wee-Siong Sho, Seah, Jun Wen Eugene, Harrison, Emily J., Chen, Caifu, Hammell, Christopher M., Hannon, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Resource/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015493/
https://www.ncbi.nlm.nih.gov/pubmed/24696458
http://dx.doi.org/10.1101/gad.235622.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015493/
https://www.ncbi.nlm.nih.gov/pubmed/24696458
http://dx.doi.org/10.1101/gad.235622.113

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