Cargando…

Dph7 Catalyzes a Previously Unknown Demethylation Step in Diphthamide Biosynthesis

[Image: see text] Present on archaeal and eukaryotic translation elongation factor 2, diphthamide represents one of the most intriguing post-translational modifications on proteins. The biosynthesis of diphthamide was proposed to occur in three steps requiring seven proteins, Dph1–7, in eukaryotes....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Zhewang, Su, Xiaoyang, Chen, Wei, Ci, Bo, Zhang, Sheng, Lin, Hening
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015618/ https://www.ncbi.nlm.nih.gov/pubmed/24739148 http://dx.doi.org/10.1021/ja5009272

Ejemplares similares

Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis
por: Dong, Min, et al.
Publicado: (2014)

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network
por: Uthman, Shanow, et al.
Publicado: (2013)

Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe–4S] to a [4Fe–4S] Cluster in Dph1–Dph2
por: Zhang, Yugang, et al.
Publicado: (2021)

Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins
por: Mayer, Klaus, et al.
Publicado: (2017)

Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
por: Zhang, Yugang, et al.
Publicado: (2021)

DPH1 and DPH2 variants that confer susceptibility to diphthamide deficiency syndrome in human cells and yeast models
por: Ütkür, Koray, et al.
Publicado: (2023)

DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2
por: Ütkür, Koray, et al.
Publicado: (2023)

Silencing of Diphthamide Synthesis 3 (Dph3) Reduces Metastasis of Murine Melanoma
por: Wang, Lei, et al.
Publicado: (2012)

Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification
por: Lin, Zhewang, et al.
Publicado: (2016)

Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2
por: Arend, Meike, et al.
Publicado: (2023)

Diphthamide biosynthesis requires an Fe-S enzyme-generated organic radical
por: Zhang, Yang, et al.
Publicado: (2010)

A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder
por: Shankar, Suma P., et al.
Publicado: (2022)

Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis
por: Zhang, Hongliang, et al.
Publicado: (2022)

Complex Evolutionary History of Translation Elongation Factor 2 and Diphthamide Biosynthesis in Archaea and Parabasalids
por: Narrowe, Adrienne B, et al.
Publicado: (2018)

Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)
por: Schaffrath, Raffael, et al.
Publicado: (2014)

Insights into Diphthamide, Key Diphtheria Toxin Effector
por: Abdel-Fattah, Wael, et al.
Publicado: (2013)

Diphthamide affects selenoprotein expression: Diphthamide deficiency reduces selenocysteine incorporation, decreases selenite sensitivity and pre-disposes to oxidative stress
por: Mayer, Klaus, et al.
Publicado: (2018)

Influence of Membrane Phase on the Optical Properties of DPH
por: Osella, Silvio, et al.
Publicado: (2020)

Frequent DPH3 promoter mutations in skin cancers
por: Denisova, Evgeniya, et al.
Publicado: (2015)

Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage
por: de Crécy-Lagard, Valérie, et al.
Publicado: (2012)

Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen
por: Liu, Jie, et al.
Publicado: (2020)

DPH Announces Sustained Funding for Overdose-Reversing Medication Naloxone
por: Walker, Kara Odom
Publicado: (2018)

Diphthamide-deficiency syndrome: a novel human developmental disorder and ribosomopathy
por: Hawer, Harmen, et al.
Publicado: (2020)

DAVID FRANCIS VAN ZWANENBERG, DM, DCH, DPH (1922–1991)
por: Dickson, J. W.
Publicado: (1992)

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
por: Aksenov, Dmitrii A., et al.
Publicado: (2023)

Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast
por: Hawer, Harmen, et al.
Publicado: (2018)

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
por: Lv, Jian-Ming, et al.
Publicado: (2017)

VC1 catalyzes a key step in the biosynthesis of vicine in faba bean
por: Björnsdotter, Emilie, et al.
Publicado: (2021)

A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents
por: Villahermosa, Desirée, et al.
Publicado: (2017)

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1
por: McCarty, Kevin D., et al.
Publicado: (2023)

Identification and Genomic Characterization of Two Previously Unknown Magnetotactic Nitrospirae
por: Zhang, Wensi, et al.
Publicado: (2021)

An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A
por: Kim, Hak Joong, et al.
Publicado: (2011)

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes
por: Pan, Jian-Jung, et al.
Publicado: (2015)

In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters
por: Selmi-Ruby, Samia, et al.
Publicado: (2020)

DPH to Distribute Overdose Reversing Medication Naloxone March 2, 2019 at Attack Addiction 5K
por: Walker, Kara Odom
Publicado: (2019)

A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin
por: Roy, Vincent, et al.
Publicado: (2010)

The kinetic aspects of intracellular fluorescence labeling with TMA-DPH support the maturation model for endocytosis in L929 cells
Publicado: (1994)

Structure and Mechanistic Insights into Novel Iron-mediated Moonlighting Functions of Human J-protein Cochaperone, Dph4
por: Thakur, Anushikha, et al.
Publicado: (2012)

Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis
por: Dawson, Alice, et al.
Publicado: (2010)

Deciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis
por: Kobylarz, Marek J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_32jo9tdhpcjm3ctoc8qkokkv16