Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model

BACKGROUND: Dipyrithione (PTS2) is widely used as a bactericide and fungicide. Here, we investigated whether PTS2 has broad-spectrum antitumor activity by studying its cytotoxicity and proapoptotic effects in four cancer cell lines. METHODS: We used MTT assays and trypan blue staining to test the vi...

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Detalles Bibliográficos
Autores principales: Fan, Yumei, Liu, Caizhi, Huang, Yongmao, Zhang, Jie, Cai, Linlin, Wang, Shengnan, Zhang, Yongze, Duan, Xianglin, Yin, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015681/
https://www.ncbi.nlm.nih.gov/pubmed/24139500
http://dx.doi.org/10.1186/2050-6511-14-54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015681/
https://www.ncbi.nlm.nih.gov/pubmed/24139500
http://dx.doi.org/10.1186/2050-6511-14-54

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