Cargando…

HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5

BACKGROUND: Most HIV strains that enter the brain are macrophage-tropic and use the CCR5 receptor to bind and infect target cells. Because the cytoskeleton is a network of protein filaments involved in cellular movement and migration, we investigated whether CCR5 and the cytoskeleton are involved in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woollard, Shawna M, Li, Hong, Singh, Sangya, Yu, Fang, Kanmogne, Georgette D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015682/ https://www.ncbi.nlm.nih.gov/pubmed/24571616 http://dx.doi.org/10.1186/1742-4690-11-20

Ejemplares similares

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice
por: Bhargavan, Biju, et al.
Publicado: (2021)

Data in support of NFκB and JNK pathways involvement in TLR3-mediated HIV-1 transactivation, expression of IL-6 and transcription factors associated with HIV-1 replication
por: Bhargavan, Biju, et al.
Publicado: (2015)

Maraviroc: a review of its use in HIV infection and beyond
por: Woollard, Shawna M, et al.
Publicado: (2015)

Epithelial RAC1 niches in IBD: from barrier integrity to cytoskeletal plasticity
por: Haag, Lea-Maxie, et al.
Publicado: (2023)

Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses
por: Bhargavan, Biju, et al.
Publicado: (2019)

Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice
por: Yan, Jun, et al.
Publicado: (2022)

Alterations of CCR2 and CX3CR1 on Three Monocyte Subsets During HIV-1/Treponema pallidum Coinfection
por: Guo, Na, et al.
Publicado: (2020)

SARS-CoV-2 Spike Proteins and Cell–Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis
por: Bhargavan, Biju, et al.
Publicado: (2022)

SARS-CoV-2 Spike Proteins and Cell–Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for the Pathogenesis of COVID-19 Coagulopathy
por: Bhargavan, Biju, et al.
Publicado: (2023)

A FAKtual Retelling of Blood-Testis Barrier and Cytoskeletal Regulation
por: Ferrer, Pierre, et al.
Publicado: (2021)

Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes
por: Sozzani, Silvano, et al.
Publicado: (1998)

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization
por: Machesky, Laura M., et al.
Publicado: (1997)

CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation
por: Kim, Jong Youl, et al.
Publicado: (2022)

CCR5 Inhibitors and HIV-1 Infection
por: Latinovic, Olga S., et al.
Publicado: (2019)

Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy
por: Acharya, Arpan, et al.
Publicado: (2020)

The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics
por: Wang, X., et al.
Publicado: (2018)

Interleukin 1beta mediates the modulatory effects of monocytes on LNCaP human prostate cancer cells.
por: Culig, Z., et al.
Publicado: (1998)

KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells
por: Zhang, Hui, et al.
Publicado: (2022)

Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction
por: Xing, Hao, et al.
Publicado: (2022)

Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells
por: Suidan, Georgette L., et al.
Publicado: (2008)

Control of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestrated
por: Sáenz‐Narciso, Beatriz, et al.
Publicado: (2016)

The Role of Cytoskeletal Proteins in the Formation of a Functional In Vitro Blood-Brain Barrier Model
por: Mentor, Shireen, et al.
Publicado: (2022)

Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications
por: Teto, Georges, et al.
Publicado: (2016)

Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection
por: Espíndola, Milena S., et al.
Publicado: (2018)

Nogo-B is associated with cytoskeletal structures in human monocyte-derived macrophages
por: Schanda, Kathrin, et al.
Publicado: (2011)

Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption
por: Willenbring, Robin C., et al.
Publicado: (2016)

Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice
por: Fan, Li, et al.
Publicado: (2018)

Immune modulatory effects of progesterone on oxLDL‐induced trained immunity in monocytes
por: Groh, Laszlo A., et al.
Publicado: (2022)

Monocytes Infiltrate the Pancreas via the MCP-1/CCR2 Pathway and Differentiate into Stellate Cells
por: Ino, Kazuko, et al.
Publicado: (2014)

CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration
por: Fox, James M., et al.
Publicado: (2018)

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon
por: Teto, Georges, et al.
Publicado: (2017)

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors
por: Manchanda, Parmeet K., et al.
Publicado: (2012)

CCR2 on CD14(+)CD16(+) monocytes is a biomarker of HIV-associated neurocognitive disorders
por: Williams, Dionna W., et al.
Publicado: (2014)

The Na(+)–H(+ )exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells
por: Paradiso, Angelo, et al.
Publicado: (2004)

Microbial-derived metabolites induce actin cytoskeletal rearrangement and protect blood-brain barrier function
por: Knox, Emily G., et al.
Publicado: (2022)

Interfering with Rac1-activation during neonatal monocyte-macrophage differentiation influences the inflammatory responses of M1 macrophages
por: Fu, Hang, et al.
Publicado: (2023)

Author Correction: Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction
por: Xing, Hao, et al.
Publicado: (2023)

Targeting CCR5 trafficking to inhibit HIV-1 infection
por: Boncompain, Gaelle, et al.
Publicado: (2019)

Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor
por: Tsou, Chia-Lin, et al.
Publicado: (1998)

HIV-1 and methamphetamine alter galectins -1, -3, and -9 in human monocyte-derived macrophages
por: Grabowska, Kinga, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7okia80mdvergatb217eq790jc