The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

BACKGROUND: Microtubule stabilizers suppress microtubule dynamics and, at the lowest antiproliferative concentrations, disrupt the function of mitotic spindles, leading to mitotic arrest and apoptosis. At slightly higher concentrations, these agents cause the formation of multiple mitotic asters wit...

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Detalles Bibliográficos
Autores principales: Risinger, April L, Riffle, Stephen M, Lopus, Manu, Jordan, Mary A, Wilson, Leslie, Mooberry, Susan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015978/
https://www.ncbi.nlm.nih.gov/pubmed/24576146
http://dx.doi.org/10.1186/1476-4598-13-41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015978/
https://www.ncbi.nlm.nih.gov/pubmed/24576146
http://dx.doi.org/10.1186/1476-4598-13-41

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