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Interplay of Sequence, Topology and Termini Charge in Determining the Stability of the Aggregates of GNNQQNY Mutants: A Molecular Dynamics Study
This study explores the stabilities of single sheet parallel systems of three sequence variants of (1)GNNQQNY(7), N2D, N2S and N6D, with variations in aggregate size (5–8) and termini charge (charged or neutral). The aggregates were simulated at 300 and 330 K. These mutations decrease amyloid format...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015988/ https://www.ncbi.nlm.nih.gov/pubmed/24817093 http://dx.doi.org/10.1371/journal.pone.0096660 |