Novel Polyglutamine Model Uncouples Proteotoxicity from Aging

Polyglutamine expansions in certain proteins are the genetic determinants for nine distinct progressive neurodegenerative disorders and resultant age-related dementia. In these cases, neurodegeneration is due to the aggregation propensity and resultant toxic properties of the polyglutamine-containin...

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Detalles Bibliográficos
Autores principales: Christie, Nakeirah T. M., Lee, Amy L., Fay, Hannah G., Gray, Amelia A., Kikis, Elise A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016013/
https://www.ncbi.nlm.nih.gov/pubmed/24817148
http://dx.doi.org/10.1371/journal.pone.0096835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016013/
https://www.ncbi.nlm.nih.gov/pubmed/24817148
http://dx.doi.org/10.1371/journal.pone.0096835

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