Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD anima...

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Detalles Bibliográficos
Autores principales: Macdonald, Douglas, Tessari, Michela A., Boogaard, Ivette, Smith, Melanie, Pulli, Kristiina, Szynol, Agnieszka, Albertus, Faywell, Lamers, Marieke B. A. C., Dijkstra, Sipke, Kordt, Daniel, Reindl, Wolfgang, Herrmann, Frank, McAllister, George, Fischer, David F., Munoz-Sanjuan, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016121/
https://www.ncbi.nlm.nih.gov/pubmed/24816435
http://dx.doi.org/10.1371/journal.pone.0096854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016121/
https://www.ncbi.nlm.nih.gov/pubmed/24816435
http://dx.doi.org/10.1371/journal.pone.0096854

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