Rehabilitating drug-induced long-QT promoters: In-silico design of hERG-neutral cisapride analogues with retained pharmacological activity

BACKGROUND: The human ether-a-go-go related gene 1 (hERG1), which codes for a potassium ion channel, is a key element in the cardiac delayed rectified potassium current, I(Kr), and plays an important role in the normal repolarization of the heart’s action potential. Many approved drugs have been wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Durdagi, Serdar, Randall, Trevor, Duff, Henry J, Chamberlin, Adam, Noskov, Sergei Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016140/
https://www.ncbi.nlm.nih.gov/pubmed/24606761
http://dx.doi.org/10.1186/2050-6511-15-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016140/
https://www.ncbi.nlm.nih.gov/pubmed/24606761
http://dx.doi.org/10.1186/2050-6511-15-14

Ejemplares similares