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Rehabilitating drug-induced long-QT promoters: In-silico design of hERG-neutral cisapride analogues with retained pharmacological activity

BACKGROUND: The human ether-a-go-go related gene 1 (hERG1), which codes for a potassium ion channel, is a key element in the cardiac delayed rectified potassium current, I(Kr), and plays an important role in the normal repolarization of the heart’s action potential. Many approved drugs have been wit...

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Detalles Bibliográficos
Autores principales:	Durdagi, Serdar, Randall, Trevor, Duff, Henry J, Chamberlin, Adam, Noskov, Sergei Y
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016140/ https://www.ncbi.nlm.nih.gov/pubmed/24606761 http://dx.doi.org/10.1186/2050-6511-15-14

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