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REDD1 is essential for stress-induced synaptic loss and depressive behavior

Major depressive disorder (MDD) affects up to 17% of the population, causing profound personal suffering and economic loss (1). Clinical and pre-clinical studies have revealed that prolonged stress and MDD are associated with neuronal atrophy of cortical and limbic brain regions (2-9), but the molec...

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Detalles Bibliográficos
Autores principales: Ota, Kristie T., Liu, Rong-Jian, Voleti, Bhavya, Maldonado-Aviles, Jaime G., Duric, Vanja, Iwata, Masaaki, Dutheil, Sophie, Duman, Catharine, Boikess, Steve, Lewis, David A., Stockmeier, Craig A., DiLeone, Ralph J., Rex, Christopher, Aghajanian, George K., Duman, Ronald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016190/
https://www.ncbi.nlm.nih.gov/pubmed/24728411
http://dx.doi.org/10.1038/nm.3513