Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

BACKGROUND: Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors often relapse, leading to a dismal outcome. The histone methyltransferase EZH2...

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Detalles Bibliográficos
Autores principales: Ciarapica, Roberta, Carcarino, Elena, Adesso, Laura, De Salvo, Maria, Bracaglia, Giorgia, Leoncini, Pier Paolo, Dall’Agnese, Alessandra, Verginelli, Federica, Milano, Giuseppe M, Boldrini, Renata, Inserra, Alessandro, Stifani, Stefano, Screpanti, Isabella, Marquez, Victor E, Valente, Sergio, Mai, Antonello, Puri, Pier Lorenzo, Locatelli, Franco, Palacios, Daniela, Rota, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016511/
https://www.ncbi.nlm.nih.gov/pubmed/24575771
http://dx.doi.org/10.1186/1471-2407-14-139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016511/
https://www.ncbi.nlm.nih.gov/pubmed/24575771
http://dx.doi.org/10.1186/1471-2407-14-139

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