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Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism

BACKGROUND: Enzymes belonging to mechanistically diverse superfamilies often display similar catalytic mechanisms. We previously observed such an association in the case of the cyclic amidohydrolase superfamily whose members play a role in related steps of purine and pyrimidine metabolic pathways. T...

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Detalles Bibliográficos
Autores principales: Barba, Matthieu, Dutoit, Raphaël, Legrain, Christianne, Labedan, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016543/
https://www.ncbi.nlm.nih.gov/pubmed/24093154
http://dx.doi.org/10.1186/1752-0509-7-99