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Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver
BACKGROUND: Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of glucose homeostasis and xenobiotic and lipid metabolism and is affected by insulin...
Autores principales: | Ghiraldini, Flávia G, Silveira, André B, Kleinjan, Dirk A, Gilbert, Nick, Mello, Maria Luiza S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016577/ https://www.ncbi.nlm.nih.gov/pubmed/24581510 http://dx.doi.org/10.1186/1472-6823-14-19 |
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