In Search of the Active Metabolites of an Anticancer Piperazinedione, TW01003, in Rats

TW01003, a piperazinedione derivative designed as an antimitotic agent, exhibited potent anticancer and antiangiogenesis activities in mice. However, oral administration of this compound in rats led to poor systemic bioavailability which suggested that in vivo efficacy might come from its metabolite...

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Detalles Bibliográficos
Autores principales: Wang, Chun-Li, Chen, Ching-Kuei, Wang, Yao-Horng, Cheng, Yu-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016869/
https://www.ncbi.nlm.nih.gov/pubmed/24864259
http://dx.doi.org/10.1155/2014/793504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016869/
https://www.ncbi.nlm.nih.gov/pubmed/24864259
http://dx.doi.org/10.1155/2014/793504

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