Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity

Rare-cutting endonucleases, such as the I-PpoI, can be used for the induction of double strand breaks (DSBs) in genome editing and targeted integration based on homologous recombination. For therapeutic approaches, the specificity and the pattern of off-target effects are of high importance in these...

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Detalles Bibliográficos
Autores principales: Turkki, Vesa, Schenkwein, Diana, Timonen, Oskari, Husso, Tiia, Lesch, Hanna P., Ylä-Herttuala, Seppo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016911/
https://www.ncbi.nlm.nih.gov/pubmed/24860818
http://dx.doi.org/10.1155/2014/379340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016911/
https://www.ncbi.nlm.nih.gov/pubmed/24860818
http://dx.doi.org/10.1155/2014/379340

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